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Manganese is an essential human dietary element and is present as a coenzyme in several biological processes, which include macronutrient metabolism, bone formation, and free radical defense systems. Manganese is a critical component in dozens of proteins and enzymes. [8] The human body contains about 12 mg of manganese, mostly in the bones.
Manganese is an essential human dietary element. It is present as a coenzyme in several biological processes, which include macronutrient metabolism, bone formation, and free radical defense systems. It is a critical component in dozens of proteins and enzymes. [3] The human body contains about 12 mg of manganese, mostly in the bones.
Manganese superoxide dismutase (MnSOD) is the principal antioxidant in mitochondria. Several enzymes activated by manganese contribute to the metabolism of carbohydrates, amino acids, and cholesterol. [2] A deficiency of manganese causes skeletal deformation in animals and inhibits the production of collagen in wound healing. [3]
The five major minerals in the human body are calcium, phosphorus, potassium, sodium, and magnesium. [2] The remaining minerals are called "trace elements". The generally accepted trace elements are iron, chlorine, cobalt, copper, zinc, manganese, molybdenum, iodine, selenium, [5] and bromine; [6] there is some evidence that there may be more.
The metals copper, zinc, iron, and manganese are examples of metals that are essential for the normal functioning of most plants and the bodies of most animals, such as the human body. A few ( calcium , potassium , sodium ) are present in relatively larger amounts, whereas most others are trace metals , present in smaller but important amounts ...
The abundance of metal binding proteins may be inherent to the amino acids that proteins use, as even artificial proteins without evolutionary history will readily bind metals. [8] Most metals in the human body are bound to proteins. For instance, the relatively high concentration of iron in the human body is mostly due to the iron in hemoglobin.
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Trace metals within the human body include iron, lithium, zinc, copper, chromium, nickel, cobalt, vanadium, molybdenum, manganese and others. [1] [2] [3] Some of the trace metals are needed by living organisms to function properly and are depleted through the expenditure of energy by various metabolic processes of living organisms.