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Raloxifene is a selective estrogen receptor modulator (SERM) and therefore a mixed agonist–antagonist of the estrogen receptor (ER). [6] It has estrogenic effects in bone and antiestrogenic effects in the breasts and uterus. [6] Raloxifene was approved for medical use in the United States in 1997. [6] It is available as a generic medication.
Raloxifene belongs to the second-generation benzothiophene SERM drugs. It has a high affinity for the ER with potent antiestrogenic activity and tissue-specific effects distinct from estradiol. [19] Raloxifene is an ER agonist in bone and the cardiovascular system, but in breast tissue and the endometrium it acts as an ER antagonist.
One of the largest breast cancer prevention studies ever, [2] it included 22,000 women in 400 medical centers in the United States and Canada. [3] [4] [5]The study concluded that raloxifene caused fewer side-effects and less endometrial cancer than tamoxifen.
Raloxifene chemical structure. Raloxifene is a known chemical compound used to treat osteoporosis. As a result of drug repositioning experiments, the E4C project identified raloxifene as a possible candidate to treat early-stage COVID-19 patients, [6] [5] aiming to prevent clinical progression. [25]
A report in September 2009 from Health and Human Services' Agency for Healthcare Research and Quality suggests that tamoxifen, raloxifene, and tibolone used to treat breast cancer significantly reduce invasive breast cancer in midlife and older women, but also increase the risk of adverse side effects.
She is only 5 or 6 years old, a very active German Rottweiler and Black Mouth Cur mix, and about 80 pounds." It is hard to suggest a treatment without knowing the cause of the cancer.
Biden's political remark did not sit well with conservatives, who slammed him for using the opportunity to attack instead of merely honoring Carter's legacy -- and for having the audacity to speak ...
The alleged incident occurred on Tuesday, Dec. 3, while 11 students and seven staff members visited the Cracker Barrel in Waldorf, according to a Dec. 5 statement from Superintendent of Charles ...