Search results
Results from the WOW.Com Content Network
In chemistry, the hydrogenation of carbon–nitrogen double bonds is the addition of the elements of dihydrogen (H 2) across a carbon–nitrogen double bond, forming amines or amine derivatives. [1] Although a variety of general methods have been developed for the enantioselective hydrogenation of ketones, [ 2 ] methods for the hydrogenation of ...
The intermediate imine can be isolated or reacted in-situ with a suitable reducing agent (e.g., sodium borohydride) to produce the amine product. [2] Intramolecular reductive amination can also occur to afford a cyclic amine product if the amine and carbonyl are on the same molecule of starting material. [4]
The first amine adduct of borane was derived from trimethylamine. Borane tert-butylamine complex is prepared by the reaction of sodium borohydride with t-butylammonium chloride. Generally adduct are more robust with more basic amines. Variations are also possible for the boron component, although primary and secondary boranes are less common. [8]
The catalytic hydrogenation of nitriles is often the most economical route available for the production of primary amines. [3] Catalysts for the reaction often include group 10 metals such as Raney nickel , [ 4 ] [ 5 ] [ 6 ] palladium black , or platinum dioxide . [ 1 ]
For example, in the three-component coupling of aldehydes, amines, and activated alkenes, the aldehyde reacts with the amine to produce an imine prior to forming the aza-MBH adduct, as in the reaction of aryl aldehydes, diphenylphosphinamide, and methyl vinyl ketone, in the presence of TiCl 4, triphenylphosphine, and triethylamine: [19]
Amine ligation followed by deprotonation by base produces the palladium amide. (Chelating systems have been shown to undergo these two steps in reverse order, with base complexation preceding amide formation.) This key intermediate reductively eliminates to produce the product and regenerate the catalyst.
fcafotodigital - Getty Images Farro One cup cooked farro contains 6.5 grams of protein and six grams of fiber , as well as B-vitamins, red blood cell-supporting iron and magnesium.
The Knoevenagel condensation is a key step in the commercial production of the antimalarial drug lumefantrine (a component of Coartem): [8] Final step in Lumefantrine synthesis The initial reaction product is a 50:50 mixture of E and Z isomers but beecause both isomers equilibrate rapidly around their common hydroxyl precursor, the more stable ...