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Positive feedback loops, on their own or in combination with negative feedback are a common feature of oscillating biological systems. [2] Examples
NEDD4-1, an E3 ligase that recognises PTEN for degradation is up-regulated by the PI3K pathway. Therefore, when Akt is activated, PTEN is further repressed in a positive feedback loop. [23] The pathway is also controlled by protein phosphatase 2A (PP2A), which dephosphorylates Akt at Thr308 and phosphatase PHLPP dephosphorylates Akt at Ser473. [3]
Positive feedback is used in digital electronics to force voltages away from intermediate voltages into '0' and '1' states. On the other hand, thermal runaway is a type of positive feedback that can destroy semiconductor junctions. Positive feedback in chemical reactions can increase the rate of reactions, and in some cases can lead to explosions.
Positive feedback loops play a role by switching cells from low to high Cdk-activity. The interaction between the two types of loops is evident in mitosis. While positive feedback initiates mitosis, a negative feedback loop promotes the inactivation of the cyclin-dependent kinases by the anaphase-promoting complex.
Bistability can be generated by a positive feedback loop with an ultrasensitive regulatory step. Positive feedback loops, such as the simple X activates Y and Y activates X motif, essentially link output signals to their input signals and have been noted to be an important regulatory motif in cellular signal transduction because positive ...
Na + channels both open and close more quickly than K + channels, producing an influx of positive charge (Na +) toward the beginning of the action potential and an efflux (K +) toward the end. Ligand-gated sodium channels, on the other hand, create the change in the membrane potential in the first place, in response to the binding of a ligand ...
In membrane biology, the Hodgkin cycle is a key component of membrane physiology that describes bioelectrical impulses, especially prevalent in neural and muscle tissues. It was identified by British physiologist and biophysicist Sir Alan Lloyd Hodgkin.
In the physiology of the kidney, tubuloglomerular feedback (TGF) is a feedback system inside the kidneys. Within each nephron , information from the renal tubules (a downstream area of the tubular fluid ) is signaled to the glomerulus (an upstream area).