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  2. Myeloma protein - Wikipedia

    en.wikipedia.org/wiki/Myeloma_protein

    Serum protein electrophoresis showing a paraprotein (spike/peak in the gamma zone) in a patient with multiple myeloma.. A myeloma protein is an abnormal antibody (immunoglobulin) or (more often) a fragment thereof, such as an immunoglobulin light chain, that is produced in excess by an abnormal monoclonal proliferation of plasma cells, typically in multiple myeloma or Monoclonal gammopathy of ...

  3. Multiple myeloma - Wikipedia

    en.wikipedia.org/wiki/Multiple_myeloma

    A 2016 study concluded that stem cell transplant is the preferred treatment for multiple myeloma. [107] There are two types of stem cell transplants to treat multiple myeloma. [108] In autologous hematopoietic stem-cell transplantation (ASCT) – the patient's stem cells are collected from the patient's blood. The patient is given high-dose ...

  4. Minimal residual disease - Wikipedia

    en.wikipedia.org/wiki/Minimal_residual_disease

    Targets: M-protein levels in blood, patient-specific assays for immunoglobulin and T cell receptor genes (high levels of somatic hypermutation often prevent this assay from reliably working). Uses: M-protein level in the blood is standard of care and is used for almost all patients with multiple myeloma. Patient-specific assays are still ...

  5. Monoclonal gammopathy of undetermined significance - Wikipedia

    en.wikipedia.org/wiki/Monoclonal_gammopathy_of...

    MGUS resembles multiple myeloma and similar diseases, but the levels of antibodies are lower, [2] the number of plasma cells (white blood cells that secrete antibodies) in the bone marrow is lower, and it rarely has symptoms or major problems. However, since MGUS can lead to multiple myeloma, which develops at the rate of about 1.5% a year, or ...

  6. C4 Therapeutics Presents Cemsidomide Phase 1 Data at the ...

    lite.aol.com/tech/story/0022/20241208/9315853.htm

    Multiple Myeloma (MM) At the ASH Annual Meeting, C4T presented safety and anti-myeloma data demonstrating cemsidomide has the potential to become a best-in-class IKZF1/3 degrader used as a backbone therapy of choice for patients with multiple myeloma where IKZF1/3 degradation is warranted. These data support the future development of ...

  7. Smouldering myeloma - Wikipedia

    en.wikipedia.org/wiki/Smouldering_myeloma

    Smouldering myeloma is a disease classified as intermediate in a spectrum of step-wise progressive diseases termed plasma cell dyscrasias.In this spectrum of diseases, a clone of plasma cells secreting monoclonal paraprotein (also termed myeloma protein or M protein) causes the relatively benign disease of monoclonal gammopathy of undetermined significance.

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