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Fatigue is a state of tiredness (which is not sleepiness), exhaustion [1] or loss of energy. [2] [3]Fatigue (in the medical sense) is sometimes associated with medical conditions including autoimmune disease, organ failure, chronic pain conditions, mood disorders, heart disease, infectious diseases, and post-infectious-disease states. [4]
In the brain, serotonin is a neurotransmitter and regulates arousal, behavior, sleep, and mood, among other things. [9] During prolonged exercise where central nervous system fatigue is present, serotonin levels in the brain are higher than normal physiological conditions; these higher levels can increase perceptions of effort and peripheral muscle fatigue. [9]
Pain may be viewed positively, exemplified by the 'no pain, no gain' attitude, with pain seen as an essential part of training. Sporting culture tends to normalise experiences of pain and injury and celebrate athletes who 'play hurt'. [131] Pain has psychological, social, and physical dimensions, and is greatly influenced by cultural factors. [132]
Muscle fatigue is when muscles that were initially generating a normal amount of force, then experience a declining ability to generate force. It can be a result of vigorous exercise , but abnormal fatigue may be caused by barriers to or interference with the different stages of muscle contraction .
Severe fatigue may come on suddenly and make it difficult to be active at all. [33] The impact of fatigue can be severe and pose more of a problem than the pain. [35] Fatigue is a complicated, multifactorial, and vexing symptom that is highly prevalent (76%) and stubbornly persistent, as evidenced by longitudinal studies over 5 years. [36]
The Canadian Consensus Criteria require "post exertional malaise and/or [post exertional] fatigue" instead. [ 21 ] [ 22 ] [ 23 ] [ 19 ] [ 24 ] On the other hand, the older Oxford Criteria lack any mention of PEM, [ 25 ] and the Fukuda Criteria consider it optional.
In support of this, placebos (which must be mediated by a central process) have a powerful effect upon not only fatigue in prolonged exercise, [12] [13] but also upon short term endurance exercise such as sprint speed, [14] the maximum weight that could be lifted with leg extension, [15] and the tolerance of ischemic pain and power when a ...
Pain relievers, corticosteroids, bone-loss medication, sympathetic nerve-blocking medication, intravenous ketamine, physical therapy, occupational therapy, psychotherapy, biofeedback, spinal cord stimulation [9] Juvenile fibromyalgia Widespread muskuloskeletal pain, headache, sleep disturbances, fatigue [11]