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Choline is used to synthesize acetylcholine, a neurotransmitter involved in muscle control and numerous functions of the nervous system. [2] [3] Choline is involved in early development of the brain, gene expression, cell membrane signaling, and brain metabolism. [3]
Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons. [5] [6]
The parasympathetic nervous system, which uses acetylcholine almost exclusively to send its messages, is said to be almost entirely cholinergic. Neuromuscular junctions, preganglionic neurons of the sympathetic nervous system, the basal forebrain, and brain stem complexes are also cholinergic, as are the receptor for the merocrine sweat glands.
Choline acetyltransferase was first described by David Nachmansohn and A. L. Machado in 1943. [6] A German biochemist, Nachmansohn had been studying the process of nerve impulse conduction and utilization of energy-yielding chemical reactions in cells, expanding upon the works of Nobel laureates Otto Warburg and Otto Meyerhof on fermentation, glycolysis, and muscle contraction.
Trimethylamine is a full agonist of human TAAR5, [13] [14] [15] a trace amine-associated receptor that is expressed in the olfactory epithelium and functions as an olfactory receptor for tertiary amines. [15] [16] One or more additional odorant receptors appear to be involved in trimethylamine olfaction in humans as well. [16]
[7] [8] Psychological stress increases activation in the sympathetic branch of the autonomic nervous system (ANS) resulting in increased adrenergic input to the spleen via sympathetic nerve fibers descending into lymphoid tissues. [9] [10] The main neural structure responsible for down-regulating psychological stress levels is the prefrontal ...
[8] [9] Trimethylamine and N,N-dimethylethylamine are full agonists of hTAAR5. [9] [10] [11] The amber-woody fragrance timberol antagonizes this activity of trimethylamine. [12] 3-Iodothyronamine is an inverse agonist of hTAAR5. [13] [14] Recent studies highlighted the significant role of TAAR5 in the central nervous system and periphery. Beta ...
It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters: acetylcholine + H 2 O = choline + acetate. It is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate cholinergic synaptic transmission.