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If the TSH level is normal or low and serum free T 4 ... 10 mIU/L mark regarded as the threshold for treatment. [50] ... of cases occur in women over 60 years of age ...
The therapeutic target range TSH level for patients on treatment ranges between 0.3 and 3.0 μIU/mL. [18] For hypothyroid patients on thyroxine, measurement of TSH alone is generally considered sufficient. An increase in TSH above the normal range indicates under-replacement or poor compliance with therapy.
TSH levels are determined by a classic negative feedback system in which high levels of T3 and T4 suppress the production of TSH, and low levels of T3 and T4 increase the production of TSH. TSH levels are thus often used by doctors as a screening test, where the first approach is to determine whether TSH is elevated, suppressed, or normal. [25]
Thyroid function tests (TFTs) is a collective term for blood tests used to check the function of the thyroid. [1] TFTs may be requested if a patient is thought to suffer from hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid), or to monitor the effectiveness of either thyroid-suppression or hormone replacement therapy.
T 3 is preferred, because in hypothyroidism T 3 levels may be normal. [84] The ratio of bound to unbound thyroid hormones is known as the thyroid hormone binding ratio (THBR). [ 85 ] It is also possible to measure directly the main carriers of the thyroid hormones, thyroglobulin and throxine-binding globulin. [ 86 ]
People with hyperthyroid will typically "take up" higher than normal levels of radioiodine. Normal ranges for RAI uptake are from 10 to 30%. In addition to testing the TSH levels, many doctors test for T 3, Free T 3, T 4, and/or Free T 4 for more detailed results. Free T 4 is unbound to any protein in the blood.
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When treatment is first initiated, TSH levels may be monitored as often as a frequency of every 6–8 weeks. [71] Each time the dose is adjusted, TSH levels may be measured at that frequency until the correct dose is determined. [71] Once titrated to a proper dose, TSH levels will be monitored yearly. [71]