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There is likely little or no effect of a BRCA gene mutation on overall fertility, [19] although women with a BRCA mutation may be more likely to have primary ovarian insufficiency. [20] [21] BRCA mutation carriers may be more likely to give birth to girls than boys, [22] however this observation has been attributed to ascertainment bias. [23] [24]
The chromosomal location of BRCA1 was discovered by Mary-Claire King's team at UC Berkeley in 1990. [21] After an international race to refine the precise location of BRCA1, [22] the gene was cloned in 1994 by scientists at University of Utah, National Institute of Environmental Health Sciences (NIEHS) and Myriad Genetics.
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675 12190 Ensembl ENSG00000139618 ENSMUSG00000041147 UniProt P51587 P97929 RefSeq (mRNA) NM_000059 NM_001081001 NM_009765 RefSeq (protein) NP_000050 NP_001074470 NP_033895 Location (UCSC) Chr 13: 32.32 – 32.4 Mb Chr 5: 150.45 – 150.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse BRCA2 and BRCA2 are human genes and their protein products, respectively. The official symbol ...
The ARCs are made up of partnerships between universities, NHS providers, local authorities and other organisations. [62] Based at NHS organisations, the NIHR Medtech and In vitro diagnostic Co-operatives (MICs) work with commercial companies on developing new medical technologies and research in vitro diagnostic tests. [63]
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