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It happens due to high levels of uric acid in the body. ... Certain underlying health conditions can increase the risk of gout as well: Kidney disease. Obesity. Diabetes. High blood pressure.
Gout is due to persistently elevated levels of uric acid (urate) in the blood (hyperuricemia). [ 2 ] [ 5 ] This occurs from a combination of diet, other health problems, and genetic factors. [ 1 ] [ 2 ] At high levels, uric acid crystallizes and the crystals deposit in joints, tendons , and surrounding tissues, resulting in an attack of gout. [ 1 ]
Sulfinpyrazone is a uricosuric medication used to treat gout. It also sometimes is used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane. Like other uricosurics, sulfinpyrazone works by competitively inhibiting uric acid reabsorption in the proximal tubule of the kidney.
In general, this effect is achieved by action on the proximal tubule of the kidney. Drugs that reduce blood uric acid are not all uricosurics; blood uric acid can be reduced by other mechanisms (see other Antigout Medications). Uricosurics are often used in the treatment of gout, a disease in which uric acid crystals form deposits in the joints.
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [5] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
Allopurinol hypersensitivity syndrome (AHS) typically occurs in persons with preexisting kidney failure. [3]: 119 Weeks to months after allopurinol is begun, the patient develops a morbilliform eruption [3]: 119 or, less commonly, develops one of the far more serious and potentially lethal severe cutaneous adverse reactions viz., the DRESS syndrome, Stevens Johnson syndrome, or toxic epidermal ...
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