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Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding protein [5]) that is activated by the sex hormone estrogen. In humans, ERα is encoded by the gene ESR1 (EStrogen Receptor 1). [6] [7] [8]
2101 26379 Ensembl ENSG00000173153 ENSMUSG00000024955 UniProt P11474 O08580 RefSeq (mRNA) NM_001282450 NM_001282451 NM_004451 NM_007953 RefSeq (protein) NP_001269379 NP_001269380 NP_004442 NP_031979 Location (UCSC) Chr 11: 64.31 – 64.32 Mb Chr 19: 6.89 – 6.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Estrogen-related receptor alpha (ERRα), also known as NR3B1 (nuclear ...
The first includes the intracellular estrogen receptors, namely ERα and ERβ, which belong to the nuclear receptor family. The second class consists of membrane estrogen receptors (mERs), such as GPER (GPR30), ER-X, and G q-mER, which are primarily G protein-coupled receptors. This article focuses on the nuclear estrogen receptors (ERα and ERβ).
The activation of the two different estrogen receptors has different effects on human. ERα and ERβ also mediate Selective estrogen-receptor modulators ' (SERMs') function, [ 17 ] but the selective ERα agitator can always cause some side effects such as breast cancer or endometrial hyperplasia, while the selective ERβ agitator may play an ...
The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of sequence homology with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones. There are three human estrogen related receptors: ERRα ; ERRβ ; ERRγ
Eating at least five tiny servings of dark chocolate each week may lower the risk of developing type 2 diabetes by 21%, according to a new observational study.
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