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Low energy levels and stress: The AMP-dependent protein kinase AMPK phosphorylates and thereby activates TSC1-TSC2 by phosphorylating at least 2 residues of TSC2. [7] Hypoxia: The Hypoxia-inducible factor α HIFα induces REDD1 at low oxygen levels. REDD1 has been shown to activate TSC1-TSC2 by neutralisation of AKT dependent inhibition. [8]
Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis. [8]The defective degradation of glycogen by the autophagy-lysosome pathway is, at least in part, independent of impaired regulation of mTORC1 and is restored by the combined use of PKB/Akt and mTORC1 pharmacological inhibitors.
Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin.
The 1,000th Wordle puzzle ran in March, a milestone for the popular game where players tend to stick to a formula, with 2.8 million people using the same starting word every day as proof. The most ...
An explosion sank a sanctioned Russian cargo ship in the Mediterranean Sea on Monday night, Russian authorities said, leaving two crew members missing. The crisis center of the Russian Foreign ...
Sean Manaea is set to return to the New York Mets on a $75 million, three-year contract, a person familiar with the agreement told The Associated Press. Manaea blossomed into New York's top ...
TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. TSC1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including TSC2, therefore preventing their ubiquitination and degradation in the proteasome. [6]
From January 2008 to April 2008, if you bought shares in companies when Juergen Dormann joined the board, and sold them when he left, you would have a 12.7 percent return on your investment, compared to a -5.3 percent return from the S&P 500.