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Hyperammonemia, or high ammonia levels, is a metabolic disturbance characterised by an excess of ammonia in the blood. Severe hyperammonemia is a dangerous condition that may lead to brain injury and death. It may be primary or secondary. Ammonia is a substance that contains nitrogen. It is a product of the catabolism of protein.
The resultant effect of this toxicity can be reduced brain energy metabolism and function. Importantly, the toxic effects of ammonia on astrocyte remodeling can be reduced through administration of L-carnitine. [89] This astrocyte remodeling appears to be mediated through ammonia-induced mitochondrial permeability transition.
[5] [7] This effect of environmental richness upon the brain occurs whether it is experienced immediately following birth, [8] after weaning, [5] [7] [9] or during maturity. [10] When synapse numbers increase in adults, they can remain high in number even when the adults are returned to impoverished environment for 30 days [ 10 ] suggesting ...
Ornithine transcarbamylase deficiency also known as OTC deficiency is the most common urea cycle disorder in humans. Ornithine transcarbamylase, the defective enzyme in this disorder, is the final enzyme in the proximal portion of the urea cycle, responsible for converting carbamoyl phosphate and ornithine into citrulline.
Ammonia in salt water ecosystems will have similar effects on fish as ammonia in freshwater ecosystems. Another aquatic animal that is affected by increasing amounts of ammonia is coral. Coral are very important for diversity in oceans and increasing concentrations of ammonia in the water is harming the bacteria that are found on the coral. [27]
Brain size usually increases with body size in animals (i.e. large animals usually have larger brains than smaller animals); [4] the relationship is not, however, linear. Small mammals such as mice may have a brain/body ratio similar to humans, while elephants have a comparatively lower brain/body ratio. [4] [5]
Ilya Stallone takes the quirky charm of medieval art and mashes it up with the chaos of modern life, creating comics that feel both hilarious and oddly timeless. Using a style straight out of ...
Mass effect such as brain tumor, infarction with edema, contusions, subdural or epidural hematoma, or abscesses all tend to deform the adjacent brain. [citation needed] Generalized brain swelling can occur in ischemic-anoxia states, acute liver failure, [9] hypertensive encephalopathy, hypercarbia (hypercapnia), and Reye hepatocerebral syndrome ...