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Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor , in that it was one of the first to be described.
Even though it is clear that exogenous administration of NGF helps decrease tissue inflammation, the molecular mechanisms are still unknown. [12] Moreover, blood NGF levels are increased in times of stress, during immune disease, and with asthma or arthritis, amongst other conditions. [8] [12]
Nerve growth factor (NGF), the prototypical growth factor, is a protein secreted by a neuron's target cell. NGF is critical for the survival and maintenance of sympathetic and sensory neurons. NGF is released from the target cells, binds to and activates its high affinity receptor TrkA on the neuron, and is internalized into the responsive neuron.
Brain-derived neurotrophic factor (BDNF), or abrineurin, [5] is a protein [6] that, in humans, is encoded by the BDNF gene. [7] [8] BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4/NT-5.
The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system ; it helps to support the survival and differentiation of existing neurons, and encourages the growth and ...
The news outlet reports the medication works using monoclonal antibodies that block the activity of nerve growth factor, a protein that helps transmit pain signals in the body. The drug is meant ...
In this disorder, vitamin D is believed to be involved in the development of the brain during the gestational period. Gestational vitamin D deficiency in rats is associated with reduced levels of neurotrophic factors NGF and GDNF. [7] NGF is the nerve growth factor, which is involved in neurotransmission.
13653 Ensembl ENSG00000120738 ENSMUSG00000038418 UniProt P18146 P08046 RefSeq (mRNA) NM_001964 NM_007913 RefSeq (protein) NP_001955 NP_031939 Location (UCSC) Chr 5: 138.47 – 138.47 Mb Chr 18: 34.99 – 35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse EGR-1 (Early growth response protein 1) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by ...