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In advanced lipodermatosclerosis the proximal leg swells from chronic venous obstruction and the lower leg shrinks from chronic ulceration and fat necrosis resulting in the inverted coke bottle appearance of the lower leg. [7] Lipodermatosclerosis is most commonly diagnosed in middle-aged women. [3]
The result is edema, pain and a white appearance (alba) of the leg. The next step in the disease progression is occlusion of the superficial venous system, thereby preventing all venous outflow from the extremity. At this stage it is called phlegmasia cerulea dolens. The leg becomes more swollen and increasingly more painful.
Cramp fasciculation syndrome (CFS) is a rare [1] peripheral nerve hyperexcitability disorder. It is more severe than the related (and common) disorder known as benign fasciculation syndrome ; it causes fasciculations , cramps, pain, fatigue, and muscle stiffness similar to those seen in neuromyotonia (another related condition). [ 2 ]
Signs and symptoms of PTS in the leg may include: [1] pain (aching or cramping) heaviness; itching or tingling; swelling (edema) varicose veins; brownish or reddish skin discoloration; ulcer; These signs and symptoms may vary among patients and over time.
Compartment syndrome is a condition in which increased pressure within one of the body's anatomical compartments results in insufficient blood supply to tissue within that space. [6] [7] [8] There are two main types: acute and chronic. [6] Compartments of the leg or arm are most commonly involved. [3]
[3] [4] [5] However, in studies measuring patient quality of life, patients seem to be rarely bothered by the loss of sensation. [8] While both procedures are effective, the neurectomy has better outcomes on complete pain relief. [4] [8] [5] In a systematic review, complete pain relief was seen in 85% of neurectomy cases and 63% of ...
For women, a drop in estrogen can cause weight gain, particularly in the abdomen (aka menopause belly). For men, low testosterone is linked to an increase in fat mass. Men with obesity are more ...
Spinal and bulbar muscular atrophy (SBMA), popularly known as Kennedy's disease, is a rare, adult-onset, X-linked recessive lower motor neuron disease caused by trinucleotide CAG repeat expansions in exon 1 of the androgen receptor (AR) gene, which results in both loss of AR function and toxic gain of function.
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