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The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression.
Without cyclin, CDK is less active than in the cyclin-CDK heterodimer complex. [ 5 ] [ 6 ] CDKs phosphorylate proteins on serine (S) or threonine (T) residues. The specificity of CDKs for their substrates is defined by the S/T-P-X-K/R sequence, where S/T is the phosphorylation site, P is proline, X is any amino acid, and the sequence ends with ...
The CDK is a library, instead of a user program. However, it has been integrated into various environments to make its functions available. CDK is currently used in several applications, including the programming language R, [13] CDK-Taverna (a Taverna workbench plugin), [14] Bioclipse, PaDEL, [15] and Cinfony. [16]
Anthony Davis is out at least through the All-Star break after sustaining a groin injury in his debut with the Dallas Mavericks following the seismic trade that sent Luka Doncic to the Los Angeles ...
Cyclin E/Cdk2 activity levels throughout the cell cycle. The Cyclin E/Cdk2 complex is a structure composed of two proteins, cyclin E and cyclin-dependent kinase 2 (Cdk2). ). Similar to other cyclin/Cdk complexes, the cyclin E/Cdk2 dimer plays a crucial role in regulating the cell cycle, with this specific complex peaking in activity during the G1/S transit
The CDK4 gene is located on chromosome 12 in humans. [7] The gene is composed of 4,583 base pairs which together code for the 303 amino acid protein with a molecular mass of 33,730 Da. [7] [8] All CDK proteins, including CDK4, have two lobes: the smaller N-terminal lobe (which contains an inhibitory G-loop), and the C terminal lobe (which contains an activation domain and a T-loop).
The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine kinase.This complex is one of many cyclin/cyclin-dependent kinase complexes that are the "hearts of the cell-cycle control system" [1] and govern the cell cycle and its progression.
1017 12566 Ensembl ENSG00000123374 ENSMUSG00000025358 UniProt P24941 P97377 RefSeq (mRNA) NM_001290230 NM_001798 NM_052827 NM_016756 NM_183417 RefSeq (protein) NP_001277159 NP_001789 NP_439892 NP_058036 NP_904326 Location (UCSC) Chr 12: 55.97 – 55.97 Mb Chr 10: 128.53 – 128.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase 2, also known as cell division ...