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GM2A is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. This protein binds molecules of ganglioside GM2, extracts them from membranes, and presents them to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
B7 is a type of integral membrane protein found on activated antigen-presenting cells (APC) that, when paired with either a CD28 or CD152 surface protein on a T cell, can produce a costimulatory signal or a coinhibitory signal to enhance or decrease the activity of a MHC-TCR signal between the APC and the T cell, respectively.
A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.
64115 74048 Ensembl ENSG00000107738 ENSMUSG00000020101 UniProt Q9H7M9 Q9D659 RefSeq (mRNA) NM_022153 NM_001159572 NM_028732 RefSeq (protein) NP_071436 NP_001153044 NP_083008 Location (UCSC) Chr 10: 71.75 – 71.77 Mb Chr 10: 60.18 – 60.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse V-domain Ig suppressor of T cell activation (VISTA) is a type I transmembrane protein that ...
Activator E2F proteins can then transcribe S phase promoting genes. In REF52 cells, overexpression of activator E2F1 is able to push quiescent cells into S phase. [7] While repressors E2F4 and 5 do not alter cell proliferation, they mediate G1 arrest. [2] E2F activator levels are cyclic, with maximal expression during G1/S.
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B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans is encoded by the TNFSF13B gene. [ 5 ] [ 6 ] BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived ...