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209448 Ensembl ENSG00000180818 ENSMUSG00000022484 UniProt Q9NYD6 P31257 RefSeq (mRNA) NM_017409 NM_010462 RefSeq (protein) NP_059105 NP_034592 Location (UCSC) Chr 12: 53.99 – 53.99 Mb Chr 15: 102.88 – 102.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene. Function This gene belongs to the homeobox ...
Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. [ 5 ] [ 6 ] [ 7 ] Hox-C6 expression is highest in the fallopian tube and ovary. [ 8 ] HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.
Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals. Hox proteins encode and specify the characteristics of 'position', ensuring that the correct structures form in the correct places of the body.
Oftentimes, lncRNAs are not free-floating in the nucleus and are attached to chromosomes. [2] Studies regarding HOX genes have found that lncRNAs are highly expressed in relation to the homeobox genes. Known antisense HOX lncRNAs, such as HOTAIR, are scaffolds where transcription factors bind, which makes them mediators of epigenetic regulation.
The mir-10 genes are found within the Hox gene clusters. In mammals there are four Hox gene clusters, these contain five genes encoding miRNAs (mir-10a, mir-10b, mir-196a-1, mir-196a-2 and mir-196b). The mir-10a gene is located upstream of Hoxb4 and the mir-10b gene is located upstream of Hoxd4. [9]
This gene and other HOXB genes form a gene cluster on chromosome 17 in the 17q21.32 region. [6] Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer ) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.
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15424 Ensembl ENSG00000172789 ENSMUSG00000022485 UniProt Q00444 P32043 RefSeq (mRNA) NM_018953 NM_175730 RefSeq (protein) NP_061826 NP_783857 Location (UCSC) Chr 12: 54.03 – 54.04 Mb Chr 15: 102.88 – 102.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene. Function This gene belongs to the homeobox ...