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Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [7] HOXC6 plays a role in lymphoma. The HOXC6 isoform, HOXC6-2 is an active carcinogenic for gastric cancer.
HoxC6 was found to play an important role in gastrulation in the vertebrate Xenopus. However, gastrulation was also a target in the Drosophila Antp gene. The anterior–posterior pattern mechanism is highly conserved in these genes, as its function in Xenopus is clear, but it is unclear why it would be a target in Drosophila .
Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein.
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Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4.
Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals. Hox proteins encode and specify the characteristics of 'position', ensuring that the correct structures form in the correct places of the body.
BA.2.86 features more than 30 mutations compared to omicron XBB.1.5, which was the dominant variant for most of 2023 — it's also the strain targeted in the updated COVID-19 vaccine.
The most successful FLiRT variant so far is known as KP.2 and is starting to be seen more frequently as a cause of COVID-19. These mutations have been seen before, in different variants, they are ...