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The first dose of ketamine was administered to a human by Edward Domino in 1964. Soon after, Parke-Davis filed a patent for the utilization of the anesthetic. [7] [8] With this patent, ketamine began to be used on the battlefield where it was considered the "buddy drug" because soldiers were able to administer it to one another. [9]
Ketamine potentiates the sedative effects of propofol [85] and midazolam. [86] Naltrexone potentiates psychotomimetic effects of a low dose of ketamine, [87] while lamotrigine [38] and nimodipine [39] decrease them. Clonidine reduces the increase of salivation, heart rate, and blood pressure during ketamine anesthesia and decreases the ...
Twilight anesthesia is an anesthetic technique where a mild dose of sedation is applied to induce anxiolysis (anxiety relief), hypnosis, and anterograde amnesia (inability to form new memories). The patient is not unconscious, but sedated.
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NMDA receptor antagonists induce a state called dissociative anesthesia, marked by catalepsy, amnesia, and analgesia. [1] Ketamine is a favored anesthetic for emergency patients with unknown medical history and in the treatment of burn victims because it depresses breathing and circulation less than other anesthetics.
Esketamine, sold under the brand names Spravato (for depression) and Ketanest (for anesthesia) among others, [10] [12] is the S(+) enantiomer of ketamine. [5] [13] It is a dissociative hallucinogen drug used as a general anesthetic and as an antidepressant for treatment of depression.
The last image we have of Patrick Cagey is of his first moments as a free man. He has just walked out of a 30-day drug treatment center in Georgetown, Kentucky, dressed in gym clothes and carrying a Nike duffel bag. The moment reminds his father of Patrick’s graduation from college, and he takes a picture of his son with his cell phone.
The third-quarter pass secured the first Titans touchdown of the day. The Vikings blitzed five pass rushers on third-and-10. But Tennessee's offensive line stood its ground to buy Levis time as he ...