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Chronic recurrent multifocal osteomyelitis (CRMO) is a rare condition (1:1,000,000), in which the bones have lesions, inflammation, and pain.It is called multifocal because it can appear in different parts of the body, primarily bones, and osteomyelitis because it is very similar to that disease, although CRMO appears to be without any infection.
Osteomyelitis (OM) is an infection of bone. [1] Symptoms may include pain in a specific bone with overlying redness, fever, and weakness. [1] The feet, spine, and hips are the most commonly involved bones in adults. [2] The cause is usually a bacterial infection, [1] [7] [2] but rarely can be a fungal infection. [8]
These diseases share some clinical, radiologic, and pathologic characteristics. An entity initially known as chronic recurrent multifocal osteomyelitis was first described in 1972. [1] Subsequently, in 1978, [2] several cases of were associated with blisters on the palms and soles (palmoplantar pustulosis).
The infection can be classified as acute or chronic depending on the severity of the onset of the case, [4] [5] where acute patients often experience better outcomes than those living with the chronic symptoms that are characteristic of the disease. Although vertebral osteomyelitis is found in patients across a wide range of ages, the infection ...
It is characterized by an osteomyelitis of the frontal bone, either direct or through haematogenic spread. This results in a swelling on the forehead, hence the name. The infection can also spread inwards, leading to an intracranial abscess. Pott's puffy tumor can be associated with cortical vein thrombosis, epidural abscess, subdural empyema ...
The neurodegenerative disease, seen in many football players, can cause symptoms such as memory loss, depression, aggression and motor neuron disease, according to the Mayo Clinic. CTE can only be ...
Myelitis has an extensive differential diagnosis. The type of onset (acute versus subacute/chronic) along with associated symptoms such as the presence of pain, constitutional symptoms that encompass fever, malaise, weight loss or a cutaneous rash may help identify the cause of myelitis. In order to establish a diagnosis of myelitis, one has to ...
A number of diseases can cause bone pain, including the following: Endocrine, such as hyperparathyroidism, osteoporosis, kidney failure. [7]Gastrointestinal or systemic, such as celiac disease and non-celiac gluten sensitivity (both often occur without obvious digestive symptoms), inflammatory bowel disease (including Crohn's disease and ulcerative colitis).