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Autologous stem-cell transplantation is distinguished from allogenic stem cell transplantation where the donor and the recipient of the stem cells are different people. [2] It can be also used as an Assisted reproductive technology to improve the reproductive outcomes. In a first step the bone marrow derived stem cells are mobilized.
The first physician to perform a successful human bone-marrow transplant on a disease other than cancer was Robert A. Good at the University of Minnesota in 1968. [74] In 1975, John Kersey, also of the University of Minnesota, performed the first successful bone-marrow transplant to cure lymphoma.
Haematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent haematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. [ 10 ] [ 11 ] [ 12 ] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an ...
Autotransplantation is the transplantation of organs, tissues, or even particular proteins from one part of the body to another in the same person (auto-meaning "self" in Greek [1]). The autologous tissue (also called autogenous, autogeneic, or autogenic tissue) transplanted by such a procedure is called an autograft or autotransplant. [2]
A bone marrow transplant is the process in which a patient has an infusion of healthy stem cells — the immature cells that develop into red blood cells, white blood cells and platelets — to ...
As ADSCs adhere to bone marrow endothelium, MSCs express several different molecules that increase the adhesion such as CD44 isoforms and integrins. As ADSCs transmigrate through vessels in bone marrow, interaction and signaling between stromal-derived chemokine factor -1 ( SDF-1 ) and receptor CXCR4 is the most crucial process.
Bone marrow is the soft and spongy liquid tissue in the center of some bones that makes over 200 billion new blood cells each day, according to the Cleveland Clinic. Each year, about 18,000 people ...
This process indicates that, subsequent to bone marrow transplantation, symmetrical cell divisions into two daughter hematopoietic stem cells must occur. Stem cell self-renewal is thought to occur in the stem cell niche in the bone marrow, and it is reasonable to assume that key signals present in this niche will be important in self-renewal. [2]
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