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Yohimbine, historically used as an aphrodisiac, is sometimes used in veterinary medicine (although now largely replaced by atipamezole) for reversing the effects of α 2 s such as medetomidine that are used as sedatives during surgery.
Out of the three ɑ 2-antagonists commonly used in veterinary medicine (atipamezole, yohimbine, and tolazine), atipamezole shows the highest preference for ɑ 2 - over ɑ 1-receptors, binding to them with a ratio of 8526:1. [12] It shows no preference for a particular ɑ 2-receptor subtype. [31]
Yohimbine (/ j oʊ ˈ h ɪ m b iː n /), [2] also known as quebrachine, is an indole alkaloid derived from the bark of the African tree Pausinystalia johimbe; also from the bark of the unrelated South American tree Aspidosperma quebracho-blanco. Yohimbine is an α 2-adrenergic receptor antagonist, and has been used in a variety of research ...
Yohimbine, an α 2 blocker derived from the bark of the Pausinystalia johimbe tree, has been tested to increase libido and treat erectile dysfunction. The proposed mechanism for yohimbine is blockade of the adrenergic receptors that are associated with neurotransmitters inhibition, including dopamine and nitric oxide , and thus aiding with ...
Nonselective α blockers include, A-80426, atipamezole, phenoxybenzamine, efaroxan, idazoxan [16] (experimental), [33] and SB-269,970. Yohimbine [16] is a relatively selective α 2 blocker that has been investigated as a treatment for erectile dysfunction.
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Norepinephrine (noradrenaline). Although complete selectivity between receptor agonism is rarely achieved, some agents have partial selectivity. NB: the inclusion of a drug in each category just indicates the activity of the drug at that receptor, not necessarily the selectivity of the drug (unless otherwise noted).
Rauwolscine, also known as isoyohimbine, α-yohimbine, and corynanthidine, is an alkaloid found in various species within the genera Rauvolfia and Corynanthe (including Pausinystalia). [1] It is a stereoisomer of yohimbine. [1] Rauwolscine is a central nervous system stimulant, a local anesthetic and a vague aphrodisiac. [1]
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