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IV iron infusions are administered to patients who cannot use oral supplementation to treat their deficiency, or if oral treatment has proven ineffective. [8] Oral iron supplementations are the first line of care for iron deficiency and iron deficiency anaemia. Anaemic patients are treated with iron tablets containing 100 mg to 200 mg of iron. [7]
Iron in parenteral iron preparation needs to be released by the cleavage of the surrounding complex by macrophages. [4] After reaching the bloodstream, it becomes a part of the endogenous iron pool and establishes normal human iron distribution, metabolism, and elimination. [5] Iron poisoning is a fatal medical condition.
Sodium ferric gluconate complex, sold under the brand name Ferrlecit, is an intravenously administered iron medication for the treatment of iron deficiency anemia in adults and in children aged six years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. [2]
They are given by injection. [2] Common side effects may include joint pain, rash, vomiting, and headache. [4] Serious side effects may include heart attacks, stroke, increased cancer growth, or pure red cell aplasia. [2] It is unclear if use is safe during pregnancy. [5] [6] They work similar to naturally occurring erythropoietin. [1]
The iron sucrose molecule is a polymer with two main molecules; sucrose (chemical formula C 12 H 22 O 11) and an iron (III) hydroxide (Na 2 Fe 5 O 8 •3(H 2 O)). These two components are in solution together, but are not bound to one another. [2] Iron sucrose is a type II complex, with two oxygen atoms bonded to each iron atom. [3]
Ferric derisomaltose, sold under the brand name Monoferric among others, is a medication for the treatment of iron deficiency anemia in adults who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have non-hemodialysis dependent chronic kidney disease (). [4]
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