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Clinical studies on glucosamine efficacy are divided, with some reporting relief from arthritic pain and stiffness, while others report no benefit above placebo. [4] [9] [8] [10] As of 2015, there is no evidence that consumption of glucosamine by sport participants prevents or limits joint damage after injury. [11]
Members of the glycosaminoglycan family vary in the type of hexosamine, hexose or hexuronic acid unit they contain (e.g. glucuronic acid, iduronic acid, galactose, galactosamine, glucosamine). They also vary in the geometry of the glycosidic linkage. Examples of GAGs include:
Chondroitin as a supplement is now commonly used (often in combination with glucosamine) in treating the joint disease of osteoarthritis. [2] In contrast to the symptomatic treatments, chondroitin can modify the progression of a disease process in the patient which it can be used as an alternative medicine. [ 2 ]
Studies examining the efficacy of GLP-1 drugs used for weight loss have generally quantified changes in fat and lean mass, with changes in lean mass serving as a surrogate for muscle mass.
The perks weren't as big for already-active participants, but still notable: Those in the second-lowest activity group who walked about 83 extra minutes a day could add 4.6 years to their lives ...
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