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The first article to propose Morgellons as a new disease in a scientific journal was a review article co-authored by members of the MRF and published in 2006 by the American Journal of Clinical Dermatology. [25] A 2006 article in the San Francisco Chronicle reported, "There have been no clinical studies" of Morgellons disease. [25]
A skin biopsy for the measurement of epidermal nerve fiber density is an increasingly common technique for the diagnosis of small fiber peripheral neuropathy. [13] Physicians can biopsy the skin with a 3-mm circular punch tool and immediately fix the specimen in 2% paraformaldehyde lysine-periodate or Zamboni's fixative. [20]
Pseudoxanthoma elasticum (PXE) is a genetic disease that causes mineralization of elastic fibers in some tissues. The most common problems arise in the skin and eyes, and later in blood vessels in the form of premature atherosclerosis. [2] [3] [4] PXE is caused by autosomal recessive mutations in the ABCC6 gene on the short arm of chromosome 16 ...
Skin elastosis causes Condition Distinctive features Histopathology Actinic elastosis (most common, also called solar elastosis) Elastin replacing collagen fibers of the papillary dermis and reticular dermis: Elastosis perforans serpiginosa: Degenerated elastic fibers and transepidermal perforating canals (arrow in image points at one of them) [13]
Patients may present with general fatigue, weakness, poor wound healing, anemia, and gum disease. Clinically, one of the first signs of scurvy occurs on the skin and manifests as perifollicular hemorrhage where follicles of the skin are plugged with keratin. These areas appear as bruise-like spots around the hair follicles.
The fibers that keep skin tight don’t rebound well after being severely stretched. Ask a dermatologist or facial plastic surgeon about topical vitamin C and retinoids, injectables, laser ...
Elastosis is the buildup of elastic fibers in tissues, and is a form of degenerative disease. [17] There are a multitude of causes, but the most commons cause is actinic elastosis of the skin, also known as solar elastosis , which is caused by prolonged and excessive sun exposure, a process known as photoaging .
The dermis is composed of three major types of cells: [3] fibroblasts, macrophages, and mast cells.. Apart from these cells, the dermis is also composed of matrix components such as collagen (which provides strength), elastin (which provides elasticity), and extrafibrillar matrix, an extracellular gel-like substance primarily composed of glycosaminoglycans (most notably hyaluronan ...