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To prevent steroid-induced osteoporosis, the steroid dose and duration should be as low and as short as possible. All patients on long term glucocorticoids (≥3 months) should be encouraged to do weightbearing exercise, avoid smoking and excess alcohol and take fall prevention measures. Daily calcium and vitamin d intake should be sufficient.
Particular medications can result in MRONJ, a serious but uncommon side effect in certain individuals. Such medications are frequently used to treat diseases that cause bone resorption such as osteoporosis, or to treat cancer. The main groups of drugs involved are anti-resorptive drugs, and anti-angiogenic drugs.
However, long term use of these causes resorption, degrading the bone to raise blood calcium. [1] Consequently, these drugs have been researched for the treatment of osteoporosis, [2] [3] [4] though with only limited success. [5]
Take certain medicines to treat long-term health problems, such as arthritis, asthma, lupus, or thyroid disease. Drink too much alcohol. For women, experts recommend no more than one alcoholic ...
Commonly prescribed thyroid drug levothyroxine was linked with bone mass and bone density loss in a cohort of older adults in a recent study. ... as side effects can cause problems ...
Anticoagulants – long-term use of heparin is associated with a decrease in bone density, [79] and warfarin (and related coumarins) have been linked with an increased risk in osteoporotic fracture in long-term use. [80] Proton pump inhibitors – these drugs inhibit the production of stomach acid; this is thought to interfere with calcium ...
Long-term treatment with bisphosphonates produces anti-fracture and bone mineral density effects that persist for 3–5 years after an initial 3–5 years of treatment. [2] The bisphosphonate alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%; zoledronate reduces the risk of hip fractures by 38% and of vertebral ...
Zoledronic acid, also known as zoledronate and sold under the brand name Zometa among others, [7] by Novartis among others, is a medication used to treat a number of bone diseases. [3] These include osteoporosis, high blood calcium due to cancer, bone breakdown due to cancer, Paget's disease of bone [3] and Duchenne muscular dystrophy (DMD).
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