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Semaglutide is an anti-diabetic medication used for the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management. [ 23 ] [ 24 ] [ 25 ] It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain .
In December 2024, Novo Nordisk announced the results of REDEFINE 1, one of their series of Phase III trials, testing weekly cagrilintide 2.4 mg and semaglutide 2.4 mg individually and together versus placebo in obese or overweight subjects with one or more comorbidities. [7]
In the United States, semaglutide (Wegovy) is approved by the FDA for chronic weight management. [50] The FDA guidelines say that a therapy may be approved if it results in weight loss that is statistically significant greater than placebo and generally at least five percent of body weight over six months that comes predominantly from fat mass.
Some GLP-1 agonists, such as semaglutide, are more effective than other weight loss drugs, but are still less effective than bariatric surgery in causing weight loss. [14] GLP-1 agonists' weight reduction effects come from a combination of peripheral effects as well as activity in the brain via the central nervous system. [15]
2740 14652 Ensembl ENSG00000112164 ENSMUSG00000024027 UniProt P43220 O35659 RefSeq (mRNA) NM_002062 NM_021332 RefSeq (protein) NP_002053 NP_067307 Location (UCSC) Chr 6: 39.05 – 39.09 Mb Chr 17: 31.12 – 31.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and ...
GLP1 poly-agonist peptides [1] are a class of drugs that activate multiple peptide hormone receptors including the glucagon-like peptide-1 (GLP-1) receptor.These drugs are developed for the same indications as GLP-1 receptor agonists—especially obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
Insulin icodec/semaglutide is an experimental fixed-dose combination of insulin icodec and semaglutide in development for type 2 diabetes by Novo Nordisk. [1] [2] [3]
The following foods are best when taking Ozempic or semaglutide: Lean protein. Low-fat dairy products. Non-starchy vegetables. Nuts and seeds. Whole grains. Legumes. Fresh fruit. DronG/istockphoto ...