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The term viral protein refers to both the products of the genome of a virus and any host proteins incorporated into the viral particle. Viral proteins are grouped according to their functions, and groups of viral proteins include structural proteins , nonstructural proteins , regulatory proteins , and accessory proteins. [ 1 ]
The first identified virokine was an epidermal growth factor-like protein found in myxoma viruses. [6] Much of the early work on virokines involved vaccinia virus, which was discovered to secrete proteins that promote proliferation of neighboring cells and block complement immune activity leading to inflammation. [5]
Vpr is a Human immunodeficiency virus gene and protein product. [1] [2] Vpr stands for "Viral Protein R".Vpr, a 96 amino acid 14-kDa protein, plays an important role in regulating nuclear import of the HIV-1 pre-integration complex, and is required for virus replication and enhanced gene expression from provirus in dividing or non-dividing cells such as T cells or macrophages. [3]
Pages in category "Viral proteins" The following 5 pages are in this category, out of 5 total. This list may not reflect recent changes. ...
The PIC consists of viral proteins (including Vpr, matrix and integrase), host proteins (including Barrier to autointegration factor 1) and the viral DNA. [1] The PIC enters the cellular nucleus through the nuclear pore complex without disrupting the nuclear envelope , thus allowing HIV and related retroviruses to replicate in non-dividing cells.
VPg (viral protein genome-linked) is a protein that is covalently attached to the 5′ end of positive strand viral RNA and acts as a primer during RNA synthesis in a variety of virus families including Picornaviridae, Potyviridae, Astroviridae and Caliciviridae.
There is significant variation in the consequences of viroporin depletion: while hepatitis C virus is incapable of propagation without its p7 protein viroporin, influenza A virus and HIV-1 see decreases in in vitro viral titer of 10- to 100-fold in the absence of their respective viroporins, but remain capable of propagation.
The nidoviral papain-like protease (PLPro or PLP) is a papain-like protease protein domain encoded in the genomes of nidoviruses.It is expressed as part of a large polyprotein from the ORF1a gene and has cysteine protease enzymatic activity responsible for proteolytic cleavage of some of the N-terminal viral nonstructural proteins within the polyprotein.