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Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2), also known as glycinamide ribonucleotide transformylase (GAR Tfase), [1] is an enzyme with systematic name 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase.
The enzyme from Escherichia coli consists of two alpha8-beta8 (TIM) barrels positioned face to face and thought to have evolved by gene duplication. [1] The active site lies between the tops of the two barrels, the N-terminal barrel binds 5-methyltetrahydropteroyltri-L-glutamic acid and the C-terminal barrel binds homocysteine.
N-glycosyltransferases are an unusual [a] type of glycosyltransferase which joins single hexoses to the target protein. [6] [7] [4] Attachment of sugars to the nitrogen atom in an amide group — such as the amide group of an asparagine — requires an enzyme, as the electrons of the nitrogen are delocalized in a pi-electron system with the carbon of the amide.
Thus, the two substrates of this enzyme are L-lysyl-tRNA and phosphatidylglycerol, whereas its two products are tRNA and 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol. This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is L-lysyl-tRNA:phosphatidylglycerol 3-O ...
A fucosyltransferase is an enzyme that transfers an L-fucose sugar from a GDP-fucose (guanosine diphosphate-fucose) donor substrate to an acceptor substrate.The acceptor substrate can be another sugar such as the transfer of a fucose to a core GlcNAc (N-acetylglucosamine) sugar as in the case of N-linked glycosylation, or to a protein, as in the case of O-linked glycosylation produced by O ...
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The 3 substrates of this enzyme are phenylacetyl-CoA, isopenicillin N, and H 2 O, whereas its 3 products are CoA, penicillin G, and L-2-aminohexanedioate. This enzyme belongs to the family of transferases , specifically those acyltransferases transferring groups other than aminoacyl groups.
Ofri Bibas Levi, the sister-in-law of Shiri Bibas, an Israeli hostage kidnaped during the Oct. 7 attack in southern Israel, holds a family picture of Bibas and one of her two boys, at Moshav Giv ...