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Post-exertional malaise (PEM), sometimes referred to as post-exertional symptom exacerbation (PESE) [1] or post-exertional neuroimmune exhaustion (PENE), [2] is a worsening of symptoms that occurs after minimal exertion.
If any of these serious disorders are present, the individual will usually have additional symptoms such as chest pain, a feeling of a racing heart, loss of speech or a change in vision. Many people, especially as they age, experience lightheadedness if they arise too quickly from a lying or seated position.
Low blood pressure and a fast heart rate after the event may indicate blood loss or dehydration, while low blood oxygen levels may be seen following the event in those with pulmonary embolism. [1] Routine broad panel laboratory testing detects abnormalities in <2–3% of results and is therefore not recommended.
Migraines, abdominal pain, "feeling funny" or blurred vision may also occur before or after episodes. [ 1 ] [ 3 ] Possible causes of the condition include pain or nerve stimulation on the scalp (similar to parade-ground syncope), or compression of blood vessels or nerves resulting from neck flexion or extension . [ 2 ]
When resulting from blood loss, trauma is the most common root cause, but severe blood loss can also happen in various body systems without clear traumatic injury. [3] The body in hypovolemic shock prioritizes getting oxygen to the brain and heart, which reduces blood flow to nonvital organs and extremities, causing them to grow cold, look ...
In a US study, after 10 years, 37% had developed into a defined connective tissue disease, 43% continued undifferentiated and 20% were in remission. [23] In a Spanish study, after a mean follow-up of 11±3 years, 14% had developed a definite CTD, 62% continued undifferentiated, and 24% were in remission. [25]
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More severe rhabdomyolysis is characterized by muscle pain, tenderness, weakness and swelling of the affected muscles. [10] If the swelling is very rapid, as may happen with a crush injury after someone is released from under heavy collapsed debris, the movement of fluid from the bloodstream into damaged muscle may cause low blood pressure and ...