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Arsphenamine, also known as Salvarsan or compound 606, is an antibiotic drug that was introduced at the beginning of the 1910s as the first effective treatment for the deadly infectious diseases syphilis, relapsing fever, and African trypanosomiasis. [2] [3] This organoarsenic compound was the first modern antimicrobial agent. [4]
The years show when a given drug was released onto the pharmaceutical market. This is not a timeline of the development of the antibiotics themselves. 1911 – Arsphenamine , also Salvarsan [ 1 ]
Manufactured by Hoechst AG, Salvarsan became the most widely prescribed drug in the world. It was the most effective drug for treating syphilis until penicillin became available in the 1940s. [ 19 ] Salvarsan required improvement as to side effects and solubility and was replaced in 1911 with Neosalvarsan .
Salvarsan was a synthetic drug produced to treat the STI syphilis. The drug was developed by Paul Ehrlich (1854-1915), a German medical scientist, and his team in 1909 after three years of research. Ehrlich coined the phrase ‘magic bullet’ to describe this new wonder drug.
The drug was marketed under the name Salvarsan and gained international acclaim as the "arsenic that saves" and as the first man-made antibiotic. [7] In the wake of their discovery, some sections of European society condemned Hata's and Ehrlich's 'magic bullet' because they believed that syphilis was a divine punishment for sin and immoral acts ...
A common antibiotic used to treat liver disease could give rise to an “almost untreatable” superbug, scientists warned in a new study.. The antibiotic, rifaximin, has enabled the global ...
Salvarsan was commercially introduced in 1910, and in 1913, a less toxic form, "Neosalvarsan" (Compound 914), was released in the market. These drugs became the principal treatments of syphilis until the arrival of penicillin and other novel antibiotics towards the middle of the 20th century. [7]
In 1907 Alfred Bertheim synthesized Arsphenamine, the first man-made antibiotic. In 1927 Erik Rotheim patented the first aerosol spray can. In 1933 Robert Pauli Scherer created a method to develop softgels. William Roberts studies about penicillin were continued by Alexander Fleming, who in 1928 concluded that penicillin had an antibiotic ...