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High doses of synthetic estrogens like ethinylestradiol and diethylstilbestrol can produce prominent untoward side effects like nausea, vomiting, headache, malaise, and dizziness, among others. [ 84 ] [ 85 ] [ 86 ] Conversely, natural estrogens like estradiol and conjugated estrogens are rarely associated with such effects.
Side effects of EES in men include breast tenderness, gynecomastia, feminization, sexual dysfunction, and cardiovascular complications, among others. [ 5 ] [ 2 ] EES is a synthetic estrogen and hence is an agonist of the estrogen receptor , the biological target of estrogens like estradiol .
Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is a nonsteroidal estrogen medication, which is presently rarely used. [5] [6] [7] In the past, it was widely used for a variety of indications, including pregnancy support for those with a history of recurrent miscarriage, hormone therapy for menopausal symptoms and estrogen deficiency, treatment of prostate cancer and ...
Diethylstilbestrol (DES), a synthetic nonsteroidal estrogen which was previously used clinically to support pregnancy, has been linked to a variety of long-term adverse effects in women who were treated with it during pregnancy and in their offspring. [1]
Researchers found that rats given synthetic estrogen exhibited more behaviors associated with anxiety, compared to a more natural estrogen used in a more modern form of the contraceptive pill.
EE is an estrogen similarly to natural estrogens like estradiol and conjugated estrogens (Premarin) and synthetic estrogens like diethylstilbestrol. It binds to and activates both isoforms of the estrogen receptor, ERα and ERβ. [8] In one study, EE was found to have 233% and 38% of the affinity of estradiol for the ERα and ERβ, respectively ...
Xenoestrogens are a type of xenohormone that imitates estrogen.They can be either synthetic or natural chemical compounds.Synthetic xenoestrogens include some widely used industrial compounds, such as PCBs, BPA, and phthalates, which have estrogenic effects on a living organism even though they differ chemically from the estrogenic substances produced internally by the endocrine system of any ...
Side effects of mestranol include nausea, breast tension, edema, and breakthrough bleeding among others. [10] It is an estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like estradiol. [11] Mestranol is a prodrug of ethinylestradiol in the body. [11]
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