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In 2016, GeneTex together with antibody research companies Novus Biologicals, R&D Systems, and Atlas Antibodies joined the International Working Group on Antibody Validation (IWGAV) with the intention to help standardize best practices in antibody validation. [2] [3]
HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas, and stands for Human Melanoma Black. It is used in anatomic pathology as a marker for such tumors. The specific antigen recognized by HMB-45 is now known as Pmel 17.
In July 2014, the company acquired Novus Biologicals for $60 million. [8] [9] [10] In August 2014, the company acquired ProteinSimple for $300 million. [11] In November 2014, the company agreed to acquire CyVek for $60 million plus up to an additional $135 million in earn-out payments. [12] [13] [14]
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
Cathepsin K antibodies are marketed for research into expression of this enzyme by various cells. [11] [12] [13] Merck had a cathepsin K inhibitor, odanacatib, in Phase III clinical trials for osteoporosis. In September, 2016, Merck announced they were discontinuing development of odanacatib after their own assessment of adverse events and an ...
The use of polyclonal TMEM169 antibody (NBP2-69796) of a human melanoma cell line (SK-MEL-30) in the host of rabbit demonstrates TMEM169 localization to nucleoplasm, cytosol and centrosome. [15] Strong positivity in glial cells is revealed through immunohistochemical staining of the human cerebral cortex with antibody HPA074877.
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