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The large intestine microbiota synthesize amounts of biotin estimated to be similar to the amount taken in the diet, and a significant portion of this biotin exists in the free (protein-unbound) form and, thus, is available for absorption. How much is absorbed in humans is unknown, although a review did report that human epithelial cells of the ...
Discover what this essential B vitamin can do for your body and whether you need more in your diet. Skip to main content. Subscriptions; Animals. Business. Entertainment. Fitness. Food. Games ...
Research shows that up to 60% of the weight loss from prescription medications may come from lean body mass. Muscle loss can affect strength and mobility, so eating enough protein to preserve lean ...
Normally, the amount of biotin in the body is regulated by dietary intake, biotin transporters (monocarboxylate transporter 1 and sodium-dependent multivitamin transporter), peptidyl hydrolase biotinidase (BTD), and the protein ligase holocarboxylase synthetase. When any of these regulatory factors are inhibited, biotin deficiency could occur.
Also, multiple biotin molecules can be conjugated to a protein of interest, which allows binding of multiple streptavidin, avidin or neutravidin protein molecules and increases the sensitivity of detection of the protein of interest. There is a large number of biotinylation reagents available that exploit the wide range of possible labelling ...
The former makes it difficult for the body to reuse biotin. The latter is a genetic condition that impacts how the body breaks down certain amino acids, causing those affected to change their diet ...
Without biotinidase activity, the vitamin biotin cannot be separated from foods and therefore cannot be used by the body. Biotinidase deficiency is an inherited disorder caused by mutations in the BTD gene. When biotinidase activity is deficient, biotin can be neither recycled within the body nor removed from ingested food.
The biosynthesis that is catalyzed by BCCP usually takes place in the chloroplast of plant cells. The biosynthesis performed by the BCCP protein allows for the transfer of CO 2 within active sites of the cell. [2] The biotin carboxyl carrier protein carries approximately 1 mol of biotin per 22,000 g of protein. [3]
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