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  2. Factor V Leiden - Wikipedia

    en.wikipedia.org/wiki/Factor_V_Leiden

    Factor V Leiden (rs6025 or F5 p.R506Q [1]) is a variant (mutated form) of human factor V (one of several substances that helps blood clot), which causes an increase in blood clotting (hypercoagulability).

  3. Factor V - Wikipedia

    en.wikipedia.org/wiki/Factor_V

    14067 Ensembl ENSG00000198734 ENSMUSG00000026579 UniProt P12259 O88783 RefSeq (mRNA) NM_000130 NM_007976 RefSeq (protein) NP_000121 NP_032002 Location (UCSC) Chr 1: 169.51 – 169.59 Mb Chr 1: 163.98 – 164.05 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Coagulation factor V (Factor V), also less commonly known as proaccelerin or labile factor, is a protein involved in ...

  4. Activated protein C resistance - Wikipedia

    en.wikipedia.org/wiki/Activated_protein_C_resistance

    APC resistance is the inability of protein C to cleave Factor Va and/or Factor VIIIa, which allows for longer duration of thrombin generation and may lead to a hypercoagulable state. This may be hereditary or acquired. [4] The best known and most common hereditary form is Factor V Leiden, which is responsible for more than 95% of cases. [5]

  5. Activated protein C resistance test - Wikipedia

    en.wikipedia.org/wiki/Activated_protein_C...

    [5] [9] The initiation phase accounts for less than 5% of total thrombin generation, making aPTT-based tests poorly indicative of hypercoagulability in general. [ 10 ] [ 11 ] The aPTT-based assay is more sensitive to levels of prothrombin and factor VIII , whereas the ETP-based test is more sensitive to levels of tissue factor pathway inhibitor ...

  6. Thrombophilia - Wikipedia

    en.wikipedia.org/wiki/Thrombophilia

    The minor ("type 2") thrombophilias are much more common. Factor V Leiden is present in 5% of the population of Northern European descent, but much rarer in those of Asian or African extraction. In people with thrombosis, 10% have factor V Leiden. In those who are referred for thrombophilia testing, 30–50% have the defect.

  7. Texas Woman Allegedly Killed Her Husband, Set His Truck on ...

    www.aol.com/texas-woman-allegedly-killed-her...

    A Texas woman is charged with murder after police say she fatally shot her husband, lit his truck on fire and fled the scene in a kayak. Bexar County, Texas officials found the body of Tomas ...

  8. Budd–Chiari syndrome - Wikipedia

    en.wikipedia.org/wiki/Budd–Chiari_syndrome

    Factor V Leiden is responsible for 8% of cases. [2] Other less common inherited disorders leading to the condition include factor II mutation (3%), protein C deficiency (5%), protein S deficiency (4%), and antithrombin III deficiency(1%). [2] [14] Budd–Chiari syndrome may be the presenting sign of these hypercoagulable disorders.

  9. Republicans will still have to deal with the debt ceiling in ...

    www.aol.com/republicans-still-deal-debt-ceiling...

    The legislation would also include $2.5 trillion in cuts to net mandatory spending, aimed at satisfying conservative members who oppose increasing the debt ceiling without accompanying cuts.