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Metoprolol is a beta blocker, or an antagonist of the β-adrenergic receptors. It is specifically a selective antagonist of the β 1-adrenergic receptor and has no intrinsic sympathomimetic activity. [37] Metoprolol exerts its effects by blocking the action of certain neurotransmitters, specifically adrenaline and noradrenaline.
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The β-blockers are an immensely important class of drugs due to their high prevalence of use. The discovery of β-blockers reaches back to more than 100 years ago, when early investigators came up with the idea that catecholamines were binding selectively to receptor-like structures and that this was the cause of their pharmacological actions. [3]
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Example: metoprolol, paracetamol [2] Those compounds are well absorbed and their absorption rate is usually higher than excretion. Class II – high permeability, low solubility. Example: glibenclamide, bicalutamide, ezetimibe, aceclofenac; The bioavailability of those products is limited by their solvation rate.
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