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The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s. [25] [26] [27] Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway. They are given in a one-to-five ratio in their tablet ...
Megaloblastic anaemia; Methaemoglobinaemia; Erythema multiforme; Low blood sugar; Hepatitis (liver swelling); Crystalluria (crystals in the urine); Urinary obstruction causing difficulty passing urine
Bacteraemia is a condition in which bacteria are present in the blood and may cause disease, including systemic disease such as infective endocarditis. [3] Some dental treatments may cause bacteraemia, such as tooth extractions, subgingival scaling or even simple aggressive tooth brushing by patients. [4]
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Trimethoprim-Sulfamethoxazole (Co-trimoxazole) Bactrim, Septra Sulfonamidochrysoidine (archaic) Prontosil: Tetracyclines(Bs) Demeclocycline: Declomycin: Syphilis, chlamydial infections, Lyme disease, mycoplasmal infections, acne rickettsial infections, malaria [note 1] Gastrointestinal upset; Sensitivity to sunlight
Antibiotic therapy with a sulfonamide, most commonly trimethoprim-sulfamethoxazole, is the treatment of choice. [8] People who take trimethoprim-sulfamethoxazole for other reasons, such as prevention of Pneumocystis jirovecii infection , appear to have fewer Nocardia infections, [ 9 ] although this protective effect has been considered ...
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