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Chemotherapy agents used to treat cholangiocarcinoma include 5-fluorouracil with leucovorin, [84] gemcitabine as a single agent, [85] or gemcitabine plus cisplatin, [86] irinotecan, [87] or capecitabine. [88] A small pilot study suggested possible benefit from the tyrosine kinase inhibitor erlotinib in people with advanced cholangiocarcinoma. [89]
Futibatinib, sold under the brand name Lytgobi, is an anti-cancer medication used for the treatment of cholangiocarcinoma (bile duct cancer). [ 1 ] [ 3 ] It is a kinase inhibitor. [ 1 ] [ 6 ] It is taken by mouth .
Pemigatinib, sold under the brand name Pemazyre, is an anti-cancer medication used for the treatment of bile duct cancer (cholangiocarcinoma). [5] [6] [8] [9] Pemigatinib works by blocking FGFR2 in tumor cells to prevent them from growing and spreading. [8] Pemigatinib belongs to a group of medicines called protein kinase inhibitors. [10]
Of note, AFP is most useful for monitoring if liver cancers come back after treatment rather than for initial diagnosis. [17] Cholangiocarcinoma can be detected with these commonly used tumor markers: carbohydrate antigen 19-9 (CA 19–9), carcinoembryonic antigen (CEA) and cancer antigen 125 . These tumor markers are found in primary liver ...
Ivosidenib, sold under the brand name Tibsovo, is an anti-cancer medication for the treatment of acute myeloid leukemia (AML) and cholangiocarcinoma. [6] It is a small molecule inhibitor of isocitrate dehydrogenase-1 (IDH1), which is mutated in several forms of cancer. Ivosidenib is an isocitrate dehydrogenase-1 inhibitor that works by ...
Silmitasertib is in clinical trials for use as an adjunct to chemotherapy in the treatment of cholangiocarcinoma (bile duct cancer), [1] is in phase I and II clinical trials for the treatment of recurrent Sonic Hedgehog (SHH) medulloblastoma, [2] [3] and in preclinical development for other cancers, including hematological and lymphoid ...
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A Klatskin tumor (or hilar cholangiocarcinoma) is a cholangiocarcinoma (cancer of the biliary tree) occurring at the confluence of the right and left hepatic bile ducts. The disease was named after Gerald Klatskin, who in 1965 described 15 cases and found some characteristics for this type of cholangiocarcinoma.