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These areas, called centromeres, are responsible for billions and billions of perfect DNA matches made over the course of our lifetimes, ensuring that cells can divide successfully. And when they ...
Henrietta Lacks (born Loretta Pleasant; August 1, 1920 – October 4, 1951) [2] was an African-American woman [5] whose cancer cells are the source of the HeLa cell line, the first immortalized human cell line [B] and one of the most important cell lines in medical research. An immortalized cell line reproduces indefinitely under specific ...
The story of how the HeLa cell line came to be was also the subject of a 2010 episode of the podcast Radiolab. [69] HeLa cells were the subject of a 2010 book by Rebecca Skloot, The Immortal Life of Henrietta Lacks, investigating the historical context of the cell line and how the Lacks family was involved in its use. [14]
Immortalised cell lines have undergone similar mutations, allowing a cell type that would normally not be able to divide to be proliferated in vitro. The origins of some immortal cell lines – for example, HeLa human cells – are from naturally occurring cancers.
Patient-matched embryonic stem cell lines can now be derived using somatic cell nuclear transfer (SCNT). [citation needed] Since iPSCs can be derived directly from adult tissues, they not only bypass the need for embryos, but can be made in a patient-matched manner, which means that each individual could have their own pluripotent stem cell line.
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The cells can then return to the first gap phase G1 and wait until the cycle proceeds yet again. Dosage-response curves. In 2003 Pomerening et al. provided strong evidence for this hypothesis by demonstrating hysteresis and bistability in the activation of Cdk1 in the cytoplasmic extracts of Xenopus oocytes. [4]
By the time Gey published a short abstract claiming some credit for the development of the line, the cells were already being used by scientists all over the world. [5] Due to the unusual growth capabilities of the HeLa cell line, it also contaminated many cell cultures and ruined years of research, as discovered by Stanley Gartler in 1966. [3]