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Cold sensitivity or cold intolerance is unusual discomfort felt by some people when in a cool environment. [ 1 ] Cold sensitivity may be a symptom of hypothyroidism , anemia , low body weight, iron deficiency , vitamin B 12 deficiency , fevers , fibromyalgia or vasoconstriction . [ 2 ]
Cold agglutinins, or cold autoantibodies, occur naturally in nearly all individuals. These natural cold autoantibodies occur at low titers, less than 1:64 measured at 4 °C, and have no activity at higher temperatures. Pathologic cold agglutinins occur at titers over 1:1000 and react at 28-31 °C and sometimes at 37 °C.
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Date free Free type Metacritic ; Barkley, Shut Up and Jam: Gaiden: Tales of Game's Studios Tales of Game's Studios RPG: Microsoft Windows, macOS: January 22, 2008 Freeware [9] 93 [10] The Battle for Wesnoth: David White and others David White and others Turn-based strategy: Microsoft Windows, macOS, Linux: October 2005 October 2005 Freeware [11 ...
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Anemia affects 27% of the world's population with iron-deficiency anemia accounting for more than 60% of it. [115] A moderate degree of iron-deficiency anemia affected approximately 610 million people worldwide or 8.8% of the population. [14] It is somewhat more common in females (9.9%) than males (7.8%). [14]
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Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [8] It more commonly affects people of northern European descent. [2]