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Coal tar is available as a generic medication and over the counter. [4] Side effects include skin irritation, sun sensitivity, allergic reactions, and skin discoloration. [5] It is unclear if use during pregnancy is safe for the baby and use during breastfeeding is not typically recommended. [11] The exact mechanism of action is unknown. [12]
[8] [9] However, Goeckerman therapy is considered safe although use of tar may have the side-effects of contact dermatitis and mild local burning due to tar hypersensitivity. A retrospective study by Stern et al., of 1,373 patients concluded that there was an increase in skin cancers in those receiving repeated Goeckerman treatments compared to ...
Coal tar shampoo formulations can be effective. [8] [24] Although no significant increased risk of cancer in human treatment with coal tar shampoos has been found, caution is advised since coal tar is carcinogenic in animals, and heavy human occupational exposures do increase cancer risks. [28]
Coal tar causes the skin to shed dead cells from the top layer and slows skin cell growth. [ 29 ] Salicylic acid is an approved anti-dandruff active as per the US FDA OTC drug monograph and also used in many cosmetic anti-dandruff shampoos globally.
In 1834, German chemist Friedlieb Ferdinand Runge discovered a phenol, also known as carbolic acid, which he derived in an impure form from coal tar.In August 1865, Joseph Lister applied a piece of lint dipped in carbolic acid solution to the wound of an eleven-year-old boy at Glasgow Royal Infirmary, who had sustained a compound fracture after a cart wheel had passed over his leg.
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Dithranol or anthralin (USAN and former BAN) is a hydroxyanthrone, anthracene derivative, and is used in medications applied to the skin of people with psoriasis.It is available as creams, ointment or pastes in 0.1 to 2% strengths (Drithocreme, Dithrocream, Zithranol-RR, Micanol, Psorlin, Dritho-Scalp, Anthraforte, Anthranol and Anthrascalp).
Common side effects include vomiting, black stools, diarrhea, and constipation. [1] A more serious side effect, pneumonitis, may result if aspirated into the lungs. [1] [2] Gastrointestinal obstruction and ileus are less common but serious adverse effects. [1] Use in pregnancy and breastfeeding is generally safe. [3]
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