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Dr. Alok Patel, a pediatric physician at Stanford Medicine Children's Health, explains that nitrous oxide is neurotoxic, meaning it can cause damage to brain cells. "While the effects of short ...
Long-term or habitual use can lead to severe neurological damage. [3] Nitrous oxide is said to enhance the effects of psychedelics. [6] Since nitrous oxide can cause dizziness, dissociation, and temporary loss of motor control, it is unsafe to inhale while standing up. Safer use can involve inhalation while seated to decrease risks of injury by ...
Olney's lesions, also known as NMDA receptor antagonist neurotoxicity (NAT), is a form of brain damage consisting of selective death of neurons but not glia, observed in restricted brain regions of rats and certain other animal models exposed to large quantities of psychoactive drugs that inhibit the normal operation of the neuronal NMDA receptor.
Nitrous oxide is thought to be particularly non-toxic, though heavy long-term use can lead to a variety of serious health problems linked to the destruction of vitamin B12 and folic acid. [17] [18] Nitrous oxide "whippets" are small aerosol containers designed for charging whipped cream dispensers.
Toxic encephalopathy is a neurologic disorder caused by exposure to neurotoxic organic solvents such as toluene, following exposure to heavy metals such as manganese, as a side effect of melarsoprol treatment for African trypanosomiasis, adverse effects to prescription drugs, or exposure to extreme concentrations of any natural toxin such as cyanotoxins found in shellfish or freshwater ...
As a result, the increased concentration of Ca 2+ directly increases the stress on mitochondria, resulting in excessive oxidative phosphorylation and production of reactive oxygen species (ROS) via the activation of nitric oxide synthase, ultimately leading to cell death. Aβ was also found aiding this route to neurotoxicity by enhancing neuron ...
But inhaling nitrous oxide can deliver a short-lasting high, and a 2022 study published by the Journal of Psychopharmacology found recreational nitrous oxide use has increased in recent decades.
Prolonged exposure to relatively low levels of nitrogen (II) oxide may cause persistent headaches and nausea. [18] Like chlorine gas poisoning, symptoms usually resolve themselves upon removal from further nitrogen dioxide exposure, unless there had been an episode of severe acute poisoning. [19] Treatment and management vary with symptoms.