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Squamous-cell cancers of the lip and ears have high rates of local recurrence and distant metastasis. [27] In a recent study, it has also been shown that the deletion or severe down-regulation of a gene titled Tpl2 (tumor progression locus 2) may be involved in the progression of normal keratinocytes into becoming squamous-cell carcinoma.
A meta-analysis of skin cancer prevention in high risk individuals found evidence that topical application of T4N5 liposome lotion reduced the rate of appearance of basal cell carcinomas in people with xeroderma pigmentosum, and that acitretin taken by mouth may have a skin protective benefit in people following kidney transplant.
Squamous-cell carcinoma (SCC), also known as epidermoid carcinoma, comprises a number of different types of cancer that begin in squamous cells. [1] These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts. [1]
This skin cancer tends to grow slowly and isn’t life-threatening for most people, but it needs to be treated before it can grow deep and injure nerves and blood vessels, the AAD noted.
The lip may become scaly and indurated as AC progresses. When palpated, the lip may have a texture similar to rubbing the gloved finger along sandpaper. [7] AC may occur with skin lesions of actinic keratosis or skin cancer elsewhere, particularly on the head and neck [6] since these are the most sun exposed
Localized (meaning, the cancer hasn’t spread outside the skin where it started): 75% Regional (the cancer has spread to nearby structures or lymph nodes): 61%
Merkel cell carcinoma accounts for fewer than 1% of all skin cancers — but when it metastasizes it often turns deadly.
Basal-cell carcinoma is a common skin cancer and occurs mainly in fair-skinned patients with a family history of this cancer. Sunlight is a factor in about two-thirds of these cancers; therefore, doctors recommend sunscreens with at least SPF 30.
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