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Unlike traditional antidepressants that target the neurotransmitters serotonin and/or norepinephrine, ketamine targets glutamate — the most abundant chemical messenger in the brain, Feifel said.
Ketamine crystals on a glass plate. K-hole is the feeling of getting a high enough dose of ketamine to experience a state of dissociation.This intense detachment from reality is often a consequence of accidental overconsumption of ketamine; however, some users consciously seek out the k-hole as they find the powerful dissociative effects to be quite pleasurable and enlightening.
Ketamine potentiates the sedative effects of propofol [85] and midazolam. [86] Naltrexone potentiates psychotomimetic effects of a low dose of ketamine, [87] while lamotrigine [38] and nimodipine [39] decrease them. Clonidine reduces the increase of salivation, heart rate, and blood pressure during ketamine anesthesia and decreases the ...
Ketamine infusions have been a game-changer for many with treatment-resistant depression and other mental health issues. But when Matthew Perry died from “acute effects of ketamine” a year ago ...
An autopsy report determined that Matthew Perry died of the acute effects of ketamine. ... It also can work in the brain to cause pain relief and lowers heart rate and blood pressure, Alan says.
Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]
Ketamine is a hallucinogen that was approved by the Food and Drug Administration as an anesthetic for surgery decades ago, but it’s also used illegally as a party drug.
The use of ketamine as part of a "post-clubbing experience" has also been documented. [36] Ketamine's rise in the dance culture was most rapid in Hong Kong by the end of the 1990s. [32] Ketamine use as a recreational drug has been implicated in deaths globally, with more than 90 deaths in England and Wales in the years of 2005–2013. [37]