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Microcrystalline cellulose (MCC) is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. [1] The most common form is used in vitamin supplements or tablets.
The moisture sorption properties of pharmaceutical materials such as excipients, drug formulations and packaging films are recognized as critical factors in determining their storage, stability, processing and application performance. [1] [2] Further, vapor sorption experiments can be used to study hydrate [3] and solvate [4] formation.
Despite intensified research on oral food or pharmaceutical formulations containing nanocelluloses they are not generally recognized as safe. Nanocelluloses were demonstrated to exhibit limited toxicity and oxidative stress in in vitro intestinal epithelium [ 85 ] [ 86 ] [ 87 ] or animal models.
Cellulose is the raw material in the manufacture of nitrocellulose (cellulose nitrate) which is used in smokeless gunpowder. Pharmaceuticals: Cellulose derivatives, such as microcrystalline cellulose (MCC), have the advantages of retaining water, being a stabilizer and thickening agent, and in reinforcement of drug tablets. [73]
A wide variety of binders may be used: some common ones are lactose, dibasic calcium phosphate, sucrose, corn (maize) starch, microcrystalline cellulose, povidone polyvinylpyrrolidone and modified cellulose (for example, hydroxypropyl methylcellulose and hydroxyethylcellulose).
An excipient is a substance formulated alongside the active ingredient of a medication.They may be used to enhance the active ingredient’s therapeutic properties; to facilitate drug absorption; to reduce viscosity; to enhance solubility; to improve long-term stabilization (preventing denaturation and aggregation during the expected shelf life); or to add bulk to solid formulations that have ...
Specificity for the phenolic moiety and binding to microcrystalline cellulose". Microbiology. 140 (4): 779–787. doi: 10.1099/00221287-140-4-779. Kroon PA, Faulds CB, Williamson G (June 1996). "Purification and characterization of a novel esterase induced by growth of Aspergillus niger on sugar-beet pulp". Biotechnol. Appl. Biochem. 23 (3 ...
The tablets contain lactose monohydrate, low substituted hydroxypropyl cellulose, povidone, microcrystalline cellulose, magnesium stearate, hypromellose, polyethylene glycol, talc, and titanium dioxide in addition to the API; the oral suspension contains sorbitol, microcrystalline cellulose, carboxymethylcellulose sodium, poloxamer, simethicone ...
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