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Microcrystalline cellulose (MCC) is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. [1] The most common form is used in vitamin supplements or tablets.
[14] [15] This material was later referred to as microcrystalline cellulose (MCC) and commercialised under the name Avicel by FMC Corporation. [16] Nanocellulose gel (probably MFC of NFC) Microfibrillated cellulose (MFC) was discovered later, in the 1980s, by Turbak, Snyder and Sandberg at the ITT Rayonier labs in Shelton, Washington.
Figure 1 shows a typical water sorption result from a DVS measurement for a microcrystalline cellulose sample. The kinetic data (Figure 1a) shows the change in mass and humidity as a function of time. From the kinetic results, the rate of water uptake and water diffusion coefficients can be determined.
Cellulose is the raw material in the manufacture of nitrocellulose (cellulose nitrate) which is used in smokeless gunpowder. Pharmaceuticals: Cellulose derivatives, such as microcrystalline cellulose (MCC), have the advantages of retaining water, being a stabilizer and thickening agent, and in reinforcement of drug tablets. [73]
A wide variety of binders may be used: some common ones are lactose, dibasic calcium phosphate, sucrose, corn (maize) starch, microcrystalline cellulose, povidone polyvinylpyrrolidone and modified cellulose (for example, hydroxypropyl methylcellulose and hydroxyethylcellulose).
The polymer should be readily available and should not be very expensive. Film obtained should be tough enough so that there won't be any damage while handling or during transportation. Combination of microcrystalline cellulose and maltodextrin has been used to formulate Oral Strips of piroxicam made by hot melt extrusion technique.
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Malvern Panalytical is a Spectris plc company. [6] The company is a manufacturer and supplier of laboratory analytical instruments. [7] [8] It has been influential in the development of the Malvern Correlator, [9] and it remains notable for its work in the advancement of particle sizing technology. [10]
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