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  2. Biological half-life - Wikipedia

    en.wikipedia.org/wiki/Biological_half-life

    Absorption half-life 1 h, elimination half-life 12 h. Biological half-life ( elimination half-life , pharmacological half-life ) is the time taken for concentration of a biological substance (such as a medication ) to decrease from its maximum concentration ( C max ) to half of C max in the blood plasma .

  3. Clopidogrel - Wikipedia

    en.wikipedia.org/wiki/Clopidogrel

    Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent (dual antiplatelet therapy). [10]

  4. Adenosine diphosphate receptor inhibitor - Wikipedia

    en.wikipedia.org/wiki/Adenosine_diphosphate...

    Metabolism of ticlopidine, clopidogrel and prasugrel to an active metabolite. Clopidogrel is a prodrug that is metabolized by two pathways. In one of the pathway most of the dose of clopidogrel (85%) is hydrolyzed by esterases to an inactive carboxylic acid derivate and rapidly cleared via glucoridination followed by renal excretion.

  5. Tirzepatide - Wikipedia

    en.wikipedia.org/wiki/Tirzepatide

    [10] [13] It is sold under the brand name Mounjaro for diabetes treatment, [10] and Zepbound for weight loss and treatment of obstructive sleep apnea. [ 11 ] [ 17 ] Tirzepatide is a gastric inhibitory polypeptide analog and GLP-1 receptor agonist . [ 11 ]

  6. Peak-to-trough ratio - Wikipedia

    en.wikipedia.org/wiki/Peak-to-trough_ratio

    Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...

  7. 73% of small business owners optimistic about 2025 economy - AOL

    www.aol.com/73-small-business-owners-optimistic...

    NEXT surveyed 1,500 small business owners aged 18-64 across industries and regions in late October and November 2024 to share findings about how economic factors are shaping business in the new year.

  8. Cangrelor - Wikipedia

    en.wikipedia.org/wiki/Cangrelor

    The CHAMPION PHOENIX trial was a randomized study of over 11,000 patients published in 2013. It found usefulness of cangrelor in patients getting cardiac stents. Compared with clopidogrel given around the time of stenting, intravenous ADP-receptor blockade with cangrelor significantly reduced the rate of stent thrombosis and myocardial ...

  9. Vorapaxar - Wikipedia

    en.wikipedia.org/wiki/Vorapaxar

    In this three-year study, the addition of vorapaxar to standard of care (aspirin and/or an ADP antagonist such as clopidogrel) significantly reduced the risk of the primary composite endpoint of cardiovascular death, heart attack, stroke, or urgent coronary revascularization by 12 percent compared to placebo plus standard of care. Vorapaxar ...