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Rectal administration (colloquially known as boofing or plugging) uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels, [Note 1] and flow into the body's circulatory system, which distributes the drug to the body's organs and bodily systems.
Oral administration of a liquid. In pharmacology and toxicology, a route of administration is the way by which a drug, fluid, poison, or other substance is taken into the body. [1] Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration ...
Methods of administration include oral, sublingual (dissolving the drug under the tongue), and rectal. Parenteral administration is via a peripheral or central vein. [1] In pharmacology, the route of drug administration is important because it affects drug metabolism, drug clearance, and thus dosage. The term is from Greek enteros 'intestine'.
The Macy Catheter is a specialized catheter designed to provide comfortable and discreet administration of ongoing medications via the rectal route. The catheter was developed to make rectal access more practical and provide a way to deliver and retain liquid formulations in the distal rectum so that health practitioners can leverage the established benefits of rectal administration.
As the rectal walls expand due to the materials filling it from within, stretch receptors from the nervous system located in the rectal walls stimulate the desire to pass feces, a process called defecation. [11] An internal and external anal sphincter, and resting contraction of the puborectalis, prevent leakage of feces (fecal incontinence).
Route of administration refers to the path a drug takes to enter the body, [10] whereas drug delivery also encompasses the engineering of delivery systems and can include different dosage forms and devices used to deliver a drug through the same route. [11] Common routes of administration include oral, parenteral (injected), sublingual, topical ...
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Progesterone can be taken by rectal administration. [156] [18] [22] A suppository sold under the brand name Cyclogest is indicated for rectal use in addition to the vaginal route. [33] [157] [158] Daily rectal administration of progesterone is inconvenient and poorly accepted for long-term therapy.