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An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time."
Generally, parenteral (IV or IM) morphine is used as the standard for converting between opiates to achieve equivalent analgesic effects. These differences in morphine-equivalents may differ between formulations of the same medication, and certainly between oral and injection. [28]
Extensive research has been conducted to determine equivalence ratios comparing the relative potency of opioids. Given a dose of an opioid, an equianalgesic table is used to find the equivalent dosage of another. Such tables are used in opioid rotation practices, and to describe an opioid by comparison to morphine, the reference opioid.
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Free base conversion ratio Morphine (base) II: 9300 1 Morphine citrate II: 9300 0.81 Morphine bitartrate II: 9300 0.66 Morphine stearate II: 9300 0.51 Morphine phthalate II: 9300 0.89 Morphine hydrobromide II: 9300 0.78 Morphine hydrobromide (2 H 2 O) II: 9300 0.71 Morphine hydrochloride II: 9300 0.89 Morphine hydrochloride (3 H 2 O) II: 9300 0 ...
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Morphine sulfate pentahydrade (trade names including Dolcontin) has a higher molecular mass than morphine base, and therefore 10 mg morphine sulfate pentahydrate contains approximatively 7.5 mg of morphine free base. [11] Extended-release morphine can be administered together with "rescue doses" of immediate-release morphine pro re nata in case ...